Highland is the city the Morgendorffers claim to move to Lawndale from in the first episode (Esteemsters). It is never officially explained why they left, but a strange offhand comment by Daria to Helen in Esteemsters may be a clue, or just a clever joke.

Helen: dont want it to be Highland all over again?
Daria: Not much chance of that happening, unless theres uranium in the drinking water here too.

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